ANNO: Mutationem

ANNO: Mutationem ANNO: Mutationem blends cyberpunk action-adventure with 2D-to-3D exploration. Play as Ann, use melee and ranged combos, hunt criminals, and earn rewards to upgrade gear.

ANNO: Mutationem

ANNO: Mutationem is an action-adventure game with a strong cyberpunk vibe. You’ll explore different city locations, follow the story, and slowly uncover what’s really going on. Play as a hunter-bartender who teams up with companions to track down ruthless criminals—switching between melee and ranged weapons to chain combos and thin out massive waves of enemies, while earning rewards you can use to improve Ann’s stats, skills, and gear.

On top of the main adventure, the game includes plenty of mini-games. They can grant extra loot, chips, and crafting materials—helping you build and power up even stronger weapons.

Features

Explore and discover

This world is packed with surprises. While you progress through the campaign, you can chat with a cyborg corgi, take on part-time bartender duties, hunt down notorious criminals, and even reveal the real identity behind a popular V-streamer. From places like Neon Noctis Town to an offshore cargo ship and vast underground complexes, you can roam freely and play your way.

Switch viewpoints your way

Enjoy a distinctive 2D-to-3D style that blends two modes together smoothly. You can move between 2D action and platforming and 3D exploration, letting you interact with the environment and the people around you. Step into pixel gameplay from a fresh angle.

Ann brings the fight

Ann can cut through enemies with fast slashes, gunfire, combos, grenade throws, and powerful ground-pound attacks. From heavy greatswords to twin blades, from pistols to rocket launchers and uppercuts—this is your chance to become the one-girl force you were meant to be.

Puzzle-piece story, cyberpunk atmosphere

The narrative unfolds in a rich, dark cyberpunk world. You’ll follow Ann Flores and her hyper-hacking sidekick, Ayane, as they chase a personal mystery—where Ann’s missing brother has gone. Of course, the deeper you go, the more twists you uncover.

Gear up—seriously

Collect, purchase, or craft items to upgrade Ann’s stats, skills, and equipment. Use chips to alter and enhance weapons you find. Equip Ann and prepare her for all kinds of threats, including human foes and more.

Highlights

Visual Style

• Pixelated 2D character art blended with detailed 3D environments for a striking cyberpunk look.

Combat System

• Fight with Ann’s combat style in smooth, fast-paced battles.

Exploration

• Roam neon streets, talk with NPCs, and uncover hidden spots packed with secrets and rewards.

Storyline

• A tense, mysterious plot full of twists and momentum that keeps you guessing.

RPG Progression

• Upgrade Ann’s abilities, customize her gear, and adjust your approach as challenges evolve.

Side Missions and Mini-Games

• Take breaks from the main story with entertaining mini-games and rewarding side quests.

Strategies

Manage Your Inventory

Consumables matter throughout the game, and some are significantly more valuable than others. At the start, you can carry only five items in your backpack. You may stack up to five of the same item in one slot; after that, you’ll need to use another slot for additional stacks.

Stim Shots are especially important during the first half of the game, though they’ll eventually be replaced by the stronger Digitalin. Corn Juice is another key item.

Erythropoietin increases your damage output, while 654-2 reduces the damage you take. FM HE Grenades can freeze opponents and are powerful—but you won’t see them much until roughly the second half, often after you’ve increased your backpack capacity at least once.

Because you’ll keep finding items as you go, focus early on what’s actually useful. Don’t waste backpack space on low-priority items like Burgers, Onion Piquants, Arc Draughts, or packs of Lightning Gum. Grenades can be hit-or-miss depending on how you play, so treat them accordingly.

Do Every Side Mission

Try to complete every side mission you encounter. They aren’t overly difficult in ANNO: Mutationem, and many can be finished quickly—so you won’t be stuck grinding for hours. Even better, if you accept them casually, you may end up finishing them without too much trouble.

Some side missions reward grom points (distinct from grombits, which you earn by defeating enemies). These grom points are used to upgrade your main stats. There are just enough grom points in the game to level every stat in your talent tree—so when you see a side mission, it’s usually worth taking.

Bartending for Money

Early on in Mutationem, you’ll unlock a mini-game at your family bar. In the early stages, this game can pay out a large amount of money. The goal is to mix the drinks patrons request—matching what they want as you play.